Resume for Thomas Holton  [PDF]

EDUCATION:
      University of Tennessee, Knoxville
      Bachelor's in Liberal Arts, Music, 1994

      University of Tennessee, Knoxville
      Bachelor's in Science, Chemistry, 1995

      Temple University
      Department of Biochemistry, 1996-1997

      Texas A & M University
      Master of Science, Biochemistry, 2001

OPERATING SYSTEMS:

LANGUAGES:

EXPERIENCE:

University of California, Los Angeles, Molecular Biology Institute, Dr. David Eisenberg
August 2001 to present:Website/Database Administrator and Applications Developer

A list of activities

Texas A & M Biochemistry Department, Dr. James Sacchettini
August 1997 to August 2001:Graduate Student, Scientific Programmer

     Responsibilities include designing, programming, testing and maintaining software used in the automatic determination of protein structures from X-ray diffraction data of protein crystals. Reference: Acta Cryst.. (2000). D56, 722-734. Programs written in C on SGI (IRIX). Experience using graphics software programs, O and SPOCK, as well as X-ray data analysis and refinement programs, DENZO, CNS, CCP4, and XPLOR. Development of this software involved decision tree applications written in LISP which were designed for predicting the location of alpha carbons of proteins. Also helped design and maintain various web pages for the project and laboratory.

University of Tennessee, Knoxville, Dept. of Chemistry, Dr. Robert J. Hinde
June 1995 to July 1996 :Research Assistant

     Working in C++ on Solaris (Sun Workstation), wrote programs for predicting polyalanine secondary structure and its folding pathways. Methods used included monte carlo, simulated annealing, and statistical mechanics calculations. Possible folding pathways were determined for chains of alanine amino acids however, the methods were never extended to other types of amino acids.

Publications:

      Holton, T. R., Ioerger, T. R., Christopher, J. A., Sacchettini, J. C., "Determining Protein Structure from Electron Density Maps Using Pattern Matching", ACTA Crystallographica, 56(6), 2001, pp 722-734.

      Grimsley, J. K., Disioudi, B. D., Holton, T. R., Sacchettini, J. C., Wild, J. R., "Active site modifications of organophosphorous hydrolase for improved detoxification of organophosphorus neurotoxins", in Enzymes in Action, ed. Binne Zwanenberg, Nato Advanced Study Institute, 2000.

      Ioerger, T. R., Holton, T. R., Christopher, J. A., Sacchettini, J. C., "TEXTAL: A pattern recognition system for interpreting electron density maps", Proceedings of the Seventh International Conference on Intelligent Systems for Molecular Biology , 1999, AAAI Press, pp130-137.

REFERENCES PROVIDED UPON REQUEST.